Hepato-Pulmonary syndrome and Porto-Pulmonary Hypertension: Rare combination cause of Hypoxemia in patient with end-stage renal failure on Hemodialysis and hepatitis C Induced Decompensated Cirrhosis
Awad Magbri*, Mariam El-Magbri and Eussera El-Magbri
The case is that of 83 year-old African American man with hypertension, hepatitis C induced decompensated cirrhosis with ascites, end-stage renal disease (ESRD) on hemodialysis, fluid overload with peripheral edema and chronic hypotension. The patient was referred to the dialysis access center of Pittsburgh, PA for evaluation of his prolonged bleeding from the left upper arm brachial-basilic arterial-venous fistula (BBAVF).
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Badesch DB, Champion HC, Sanchez MA, Hoeperet MM, Loyd JE, et al. Dignosis and assessment of pulmonary arterial hypertension. J AM Coll Cardiol. 2009; 54: S55-S66. Ref.: https://goo.gl/j9YLGx
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Yigla M, Fruchter O, Aharonson D, Noa Y, Shimon A.Reisner, et al. Pulmonary hypertension is an independent predictor of mortality in hemodialysis patients. Kidney Int. 2009; 75: 969-975. Ref.: https://goo.gl/YEmGP8
Ramasubbu K, Deswal A, Herejurgen C, Aguilar D, Frost AE. A prospective echocardiographic evaluation of pulmonary hypertension in chronic hemodialysis patients in the United States: prevalence and clinical significance. Int J Gen Med. 2010; 3: 279-286. Ref.: https://goo.gl/885Eag
Bozbas SS, Akcay S, Altin C, Bozbas H, Karacaglar E, et al. Pulmonary hypertension in patients with end-stage renal disease undergoing renal transplantation. Transplant proc. 2009; 41: 2753-2756. Ref.: https://goo.gl/YG15U1
Etemadi J, Zolfaghari H, Firoozi R, Ardalan MR, Toufan M, et al. Unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patients. Rev Rort Pneumol. 2012; 18: 10-14. Ref.: https://goo.gl/dSfm9A
Fabbian F, Cantelli S, Molino C, Pala M, Longhini C, et al. Pulmonary hypertension in dialysis patients: a crosssectional Italian study. Int J Nephrol. 2010; 11: 463-475. Ref.: https://goo.gl/AqcsAu
Zlotnick DM, Axelrod DA, Chobanian MC, Scott Friedman, Brown J, et al. Noninvasive detection of pulmonary hypertension prior to renal transplantation is a predictor of increased risk for early graft dysfunction. Nephrol Dial Transplant. 2010; 25: 3090-3096. Ref.: https://goo.gl/PXpv5p
Agarwal R. Prevalence, determinants and prognosis of pulmonary hypertension among hemodialysis patients. Nephrol Dial transplant. 2012; 27: 3908-3914. Ref.: https://goo.gl/6XNkoT
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Abdelwhab S, Elshinnawy S. Pulmonary hypertension in chronic renal failure patients. Am J Nephrol. 2008; 28: 990-997. Ref.: https://goo.gl/1DC8HT
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Zoccali C, Mallamaci F, Tripepi G. Nocturnal hypoxemia predicts incident cardiovascular complications in dialysis patients. J AM Soc Nephrol. 2002; 3: 729-733. Ref.: https://goo.gl/3VLjqU
Sica AL, Greenberg HE, Ruggiero DA, Scharf SM. Chronic intermittent hypoxia: a model of sympathetic activation in the rat. Respir Physiol. 2000; 121: 173-184. Ref.: https://goo.gl/YLvv1q
Barcelo A, de la Pena M, Ayllon O, Vega-Agapito MV, Piérola J, et al. Increased plasma levels of asymmetric dimethylarginine and soluble CD40 ligand in patients with sleep apnea. Respiration. 2009; 77: 85-90. Ref.: https://goo.gl/2ZrwkF
Grassi G, Seravalle G, Ghiadoni L, Giovanni T, Rosa MB, et al. Sympathetic nerve traffic and asymmetric dimethylarginine in chronic kidney disease. Clin J Am Soc Nephrol. 2011; 6: 2620-2627. Ref.: https://goo.gl/BjivP5
Mallamaci F, Tripepi G, Maas R, Malatino L, Boger R, et al. Analysis of the relationship between norepinephrine and asymmetric dimethylarginine levels among patients with end-stage renal disease. J Am Soc Nephrol. 2004; 15: 435-441. Ref.: https://goo.gl/9PpjHh
Tripepi G, Mattace Raso F, Sijbrands E, Mohamed SS, Renke Maas, et al. Inflammation and asymmetric dimethyl arginine for predicting death and cardiovascular events in ESRD patients. Clin J Am Soc Nephrol. 2011; 6: 1714-1721. Ref.: https://goo.gl/UvfN7M
Yigla M, Abassi Z, Reisner SA, Nakhoul F. Pulmonary hypertension in hemodialysis patients: an unrecognized threat. Semin Dial. 2006; 19: 353-357. Ref.: https://goo.gl/DNKpHs
Giaid A. Nitric oxide and endothelin-1 in pulmonary hypertension. Chest. 1998; 114: 208-212. Ref.: https://goo.gl/8XaUqn
Macedo IG, Lopes EP. Hepatopulmonary syndrome. San Paulo Medical Journal. 2009; 127: 223-230. Ref.: https://goo.gl/15gzrL
Hopkins WE, Waggoner AD, Barzilai B. Frequency and significance of intrapulmonary right to left shunting in end stage liver disease. Am J Cardiol. 1992; 70: 516-519. Ref.: https://goo.gl/vybP1A
Hoeper MM, Krowka MJ, Strassburg CP. Portopulmonary hypertension and hepatopulmonary syndrome. Lancet. 2004; 363: 1461-1468. Ref.: https://goo.gl/uqiZAK
Austin MJ, Mcougall NI, Wendon J, Elizabeth S, Knisely AS, et al. Safety and efficacy of combined use of sildenafil, bosentan and IIoprost before and after liver transplantation in severe portopulmonary hypertension. 2008; 14: 287-291. Ref.: https://goo.gl/ogoZkJ
Awad Magbri*, Mariam El-Magbri and Eussera El-MagbriAwad Magbri*,Mariam El-Magbri,Eussera El-Magbri. Hepato-Pulmonary syndrome and Porto-Pulmonary Hypertension: Rare combination cause of Hypoxemia in patient with end-stage renal failure on Hemodialysis and hepatitis C Induced Decompensated Cirrhosis. . 2017 doi: 10.29328/journal.avm.1001002; 1: 008-012
Melika Loriamini, Melissa M Lewis-Bakker, Beth Binnington, Lakshmi P Kotra and Donald R Branch*Melika Loriamini, Melissa M Lewis-Bakker, Beth Binnington, Lakshmi P Kotra, Donald R Branch*. Mechanism of Small Molecule Inhibitors of Phagocytosis. J Hematol Clin Res. 2023: doi: 10.29328/journal.jhcr.1001022; 7: 011-014
Andrea Bellone*Andrea Bellone*. Advances in Physiological Research: Consideration on Arterial Hypercapnia in Acute Cardiogenic Pulmonary Edema (ACPE). Arch Case Rep. 2024: doi: 10.29328/journal.acr.1001108; 8: 116-117
Ajay B Gadicha*, Vijay B Gadicha, Mayur S Burange and ZI KhanAjay B Gadicha*,Vijay B Gadicha,Mayur S Burange,ZI Khan. Sleep Disorders and Sleep Studies Case Reports. Arch Case Rep. 2024: doi: 10.29328/journal.acr.1001114; 8: 146-151
H Pérez-Aguilar*, M Lacruz-Asaro and F Arán-AisH Pérez-Aguilar*, M Lacruz-Asaro, F Arán-Ais. Evaluation of Biostimulants Based on Recovered Protein Hydrolysates from Animal By-products as Plant Growth Enhancers. J Plant Sci Phytopathol. 2023: doi: 10.29328/journal.jpsp.1001104; 7: 042-047
H Pérez-Aguilar*, M Lacruz-Asaro and F Arán-AisH Pérez-Aguilar*, M Lacruz-Asaro, F Arán-Ais. Evaluation of Biostimulants Based on Recovered Protein Hydrolysates from Animal By-products as Plant Growth Enhancers. J Plant Sci Phytopathol. 2023 doi: 10.29328/journal.jpsp.1001104; 7: 042-047
Julian A Purrinos* and Ramzi YounisJulian A Purrinos*, Ramzi Younis. Sinonasal Myxoma Extending into the Orbit in a 4-Year Old: A Case Presentation. Arch Case Rep. 2024 doi: 10.29328/journal.acr.1001099; 8: 075-077
Denis Tonini, Kai Wu, Renata Saha and Jian-Ping Wang*Denis Tonini,Kai Wu,Renata Saha,Jian-Ping Wang*. Feasibility study of magnetic sensing for detecting single-neuron action potentials. Ann Biomed Sci Eng. 2022 doi: 10.29328/journal.abse.1001018; 6: 019-029
Khashayar Maroufi*Khashayar Maroufi*. Physical activity can change the physiological and psychological circumstances during COVID-19 pandemic: A narrative review. J Sports Med Ther. 2021 doi: 10.29328/journal.jsmt.1001051; 6: 001-007
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